the cannabis gene pool, and provides us with useful data to inform our breeding programs. We are very impressed with the work of our homie Kasper. There are thousands of studies published and reviewed on the subject of the endocannabinoid system. The endocannabinoid system and health, the endocannabinoid system is a huge part of the human body that we are just beginning to understand. Faah inhibition has shown the advantages of a lack of abuse potential or physical dependence compared with MGL. Its exciting to see new strains coming out with high levels of all these other little-known cannabinoids. The principal catabolic pathways for both AEA and 2-AG by fatty acid amide hydrolase (faah) and monoacylglycerol lipase (MGL respectively, both producing arachadonic acid. Great seeds are always the most vigorous, and generally the most predictable, but occasionally the greatest seeds can be the most unpredictable of all. In short, your ECS is responsible for the optimal function of your body - it's no small task! We are always working on developing new elite strains. We are all learning so much about the healing potential of cannabis these days. What is the endocannabinoid system? Important to note is that these two processes are mutually exclusively so that AEA and AG cannot be co-synthesized. In fact, the most important thing the endocannabinoid system wants to protect is homeostasis - that is, making sure that the body is functioning optimally at all times. This discovery was quickly followed up with further evidence. In Colorado alone, there are nine different qualifying conditions for a medical card: cancer, glaucoma, HIV or aids, cachexia (wasting syndrome persistent muscle spasms, seizures, severe nausea, severe pain, and Post Traumatic Stress Disorder (ptsd). There are so many poly-hybrids being grown these days some of which produce amazing flower but if their progeny is all over the map, its going to be harder to breed a stable strain; youre more likely to achieve better results breeding with more stable. How has demand changed over the years? Ethan Russo, a neurologist and psychopharmacology researcher, breaks down the ECS this way, the endocannabinoid system affects the levels of all the neurotransmitters, and so it is important in pain, in emotion, whether youre going to vomit or not, whether youre going to have. AEA biosynthesis is initiated following a postsynaptic neuronal depolarization and an influx of calcium. Its also found in the brain and is the receptor that THC interacts with, giving the user a high. Metabolic enzymes act like a natural referee in that they destroy endocannabinoids once they are used and no longer useful to the body. The ECS regulates a variety of biological processes, such as relaxation, feeding, sleep, certain inflammatory reactions and even cognitive function. Raphael Mechoulam, the famous chemist who discovered THC. Cannabinoids generally come from two places the human body or the cannabis plant. Were always open to cataloging new seeds in our vault but at this point in time we have so much in the way of new genetics to work with, and with our breeding facilities at full capacity, were not in a place to be wishing. To dive into these questions, its crucial to have a basic understanding of the endogenous cannabinoid system, otherwise known as the endocannabinoid system (ECS). How many different seeds are in your inventory? Every strain in the catalog is a favorite. 9, 13, 28 See the figure below. More specifically, it shows the biosynthesis of AEA and activation of the cannabinoid binding receptor-1 (CB1-R) receptor pathway (2-arachidonoylglycerol 2-AG pathway is similar but not shown here). CBD and THC are not the only compounds used by the endocannabinoid system.
The endocannabinoid system was only discovered in the early 1990s when Lisa Matsuda. A researcher at the National Institute of Mental Health. Inactivation of CB1R receptors decreases plasma insulin and leptin levels. BC God Bud still remains our most popular strain. With an understanding of the endocannabinoid system and its role in ensuring homeostasis in the body. CB2R activation is a therapeutic strategy for reducing atherosclerotic plaque inflammation and reducing vulnerability to rupture after and thrombosis.
Activation of CB1R leads to retrograde suppression of neurotransmitter release. Im actually doing this interview from Colombia where there are some famous landrace strains. The information contained in this website is for general information and educational purposes only. Which may be excitatory or inhibitory depending on the location in the brain. Kre8 medical marijuana treatment for arthritis Genetics, it allows knot in trapezius won't go away us to operate how we have always wanted to throughout those dark years of prohibition. A nonCB1RnonCB2R has been theorized based on indirect data but has yet to be characterized.
It has been an overall positive transition, with many new opportunities and relationships among professionals and the general public, now that we can all work out in the open.They are abundant in the brain and immune system.
States, breeding in those days was mostly directed at increasing potency and yield. And inflammation, auntie Dolores and Treatibles, the bestdescribed pathway is shown in the figure below. The power source for every cell in your body. Do you have a favorite cultivar to grow. Working with our ambassadors to reach these goals. If you havent acknowledged that the endocannabinoid system exists 16 It is uncertain if there is a regulatory feedback loop between the ECS and obesity.